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Of cardiovascular disease development.244 Further implicating S100 proteins in the development of chronic inflammatory diseases, calgranulins (S100A8/A9 and S100A12) were shown to be involved in the joint inflammation associated with RA.290 S100A8/A9 are highly upregulated in macrophages and neutrophils from patients with juvenile rheumatoid arthritis, and S100A8/A9 titers in the serum and synovia
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